Description

Dexbrompheniramine Maleate CAS NO 2391-03-9 is the dextrorotatory enantiomer of brompheniramine maleate, a potent and selective histamine H1-receptor antagonist. This high-purity active pharmaceutical ingredient (API) is valued for its superior efficacy and reduced side-effect profile compared to racemic mixtures, offering significant advantages in therapeutic formulation. It is essential for manufacturers in the pharmaceutical industry developing advanced antihistamine medications for allergy and cold symptom relief.

Application

• Primary Active Pharmaceutical Ingredient (API) in prescription and over-the-counter (OTC) antihistamine tablets and syrups.
• Key component in fixed-dose combination cold and flu medications, often paired with decongestants and analgesics.
• Used in pharmaceutical R&D for developing new sustained-release or fast-acting allergy formulations.
• Critical material for quality control laboratories as a reference standard for assay and impurity testing.
• Manufacturing of veterinary pharmaceutical products for allergic conditions in animals.

Basic Information

Product Name	Dexbrompheniramine Maleate
CAS No.	2391-03-9
Molecular Formula	C20H23BrN2O4
Molecular Weight	435.31 g/mol
Synonyms	(+)-Brompheniramine Maleate; d-Brompheniramine Maleate; Dexchlorpheniramine Maleate Analog; Drixoral (Active Ingredient); 2-[4-Bromo-α-(2-dimethylaminoethyl)benzyl]pyridine maleate (1:1); (3S)-3-(4-Bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine (Z)-butenedioate
EINECS	219-219-3

Quality Control

Our Dexbrompheniramine Maleate is manufactured under strict quality management systems. It is tested to meet exacting standards for pharmaceutical use, including identification, purity, and impurity profiles. Comprehensive testing ensures compliance with relevant pharmacopeial guidelines. A Certificate of Analysis (COA) detailing all test results is provided with each batch to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+30.0° to +35.0° (c=1 in water)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.