Description

3,5-Bis(Trifluoromethyl)-4-Chloro-Nitrobenzene is a high-value, multi-functional aromatic intermediate characterized by its unique trifluoromethyl and nitro substituents. This compound is critical for introducing lipophilicity and metabolic stability into target molecules, making it a sought-after building block in advanced chemical synthesis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated ligands in catalysis and molecular recognition systems.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials requiring fluorinated aromatic units.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)-4-Chloro-Nitrobenzene
CAS No.	2375-97-5
Molecular Formula	C9H2ClF6NO2
Molecular Weight	313.56 g/mol
Synonyms	4-Chloro-3,5-bis(trifluoromethyl)nitrobenzene; 1-Chloro-2,6-bis(trifluoromethyl)-4-nitrobenzene; 4-Nitro-3,5-bis(trifluoromethyl)chlorobenzene; 2,6-Bis(trifluoromethyl)-4-nitrochlorobenzene; 3,5-Bis(trifluoromethyl)-4-chloronitrobenzene; 4-Chloro-α,α,α,α',α',α'-hexafluoro-3,5-dimethylnitrobenzene; NSC 404087
EINECS	219-158-3

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)-4-Chloro-Nitrobenzene is manufactured and tested under a strict quality management system. We guarantee high-purity material suitable for demanding synthetic applications, with comprehensive testing including assay, identity confirmation, and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.