Description

Methylprednisolone Sodium Succinate CAS NO 2375-03-3 is a water-soluble ester salt of the potent glucocorticoid methylprednisolone, designed for rapid systemic administration. This compound is critical for its potent anti-inflammatory and immunosuppressive effects, making it a cornerstone in managing acute medical conditions. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the production of injectable formulations used in hospital and clinical settings.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable solutions for intravenous or intramuscular administration.
• Anti-inflammatory Therapy: Treatment of severe inflammatory conditions such as acute exacerbations of multiple sclerosis, allergic reactions, and rheumatoid arthritis.
• Immunosuppressive Therapy: Management of conditions requiring immune system modulation, including organ transplantation and certain autoimmune diseases.
• Shock and Emergency Medicine: Used in the management of septic shock, adrenal insufficiency, and other critical care scenarios.
• Parenteral Nutrition Adjunct: May be formulated in complex parenteral solutions for patients with specific inflammatory responses.
• Veterinary Pharmaceuticals: Used in high-value veterinary medicine for similar anti-inflammatory and immunosuppressive indications.

Basic Information

Product Name	Methylprednisolone Sodium Succinate
CAS No.	2375-03-3
Molecular Formula	C26H33NaO8
Molecular Weight	496.53 g/mol
Synonyms	Methylprednisolone 21-Hemisuccinate Sodium Salt; U-67590A; Solu-Medrol (brand name); 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-(sodium succinate); 6α-Methylprednisolone 21-Sodium Succinate; Methylprednisolone Hemisuccinate Sodium; Medrate Sodium Succinate
EINECS	219-157-7

Quality Control

Our Methylprednisolone Sodium Succinate is manufactured under strict quality systems. It is typically tested to meet high-purity standards relevant for pharmaceutical use, including identification, assay, and control of specific impurities and residual solvents. Certificates of Analysis (COA) are provided with each batch, detailing compliance with agreed specifications. We can supply material aligned with various pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
pH (5% solution)	6.5 - 8.0
Specific Rotation	+115° to +125° (c=1 in water)
Bacterial Endotoxins	< 0.17 EU/mg (as applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.