Description

4-(Trifluoromethyl)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. Its molecular structure, featuring a phenylacetonitrile core with a trifluoromethyl substituent, makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where the introduction of the trifluoromethyl group is key to enhancing the biological activity and metabolic stability of target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS drugs, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the CF3 group improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyanoethylation, and as a precursor to corresponding acids, esters, and amides for further functionalization.
• Material Science: Used in the synthesis of specialty polymers and advanced organic materials with unique electronic or surface properties.

Basic Information

Product Name	4-(Trifluoromethyl)Phenylacetonitrile
CAS No.	2338-75-2
Molecular Formula	C9H6F3N
Molecular Weight	185.15 g/mol
Synonyms	p-(Trifluoromethyl)phenylacetonitrile; α-(p-Trifluoromethylphenyl)acetonitrile; 4-(Trifluoromethyl)benzyl cyanide; (4-Trifluoromethylphenyl)acetonitrile; 2-[4-(Trifluoromethyl)phenyl]acetonitrile; 4-CF3-Phenylacetonitrile; p-Trifluoromethylbenzyl cyanide
EINECS	219-052-5

Quality Control

Our 4-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.