Description

6Alpha,9-Difluoro-11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative, recognized for its potent anti-inflammatory and immunosuppressive pharmacological profile. This compound serves as a critical advanced intermediate in the synthesis of modern topical corticosteroids and other specialized pharmaceutical actives. It is essential for research and development laboratories, process chemists, and manufacturers within the global pharmaceutical and fine chemical sectors seeking reliable, high-quality building blocks.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent corticosteroid APIs, such as difluprednate and related analogues.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory agents.
• Process Chemistry: Serves as a standardized building block for scaling up production processes under cGMP conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor binding and downstream signaling pathways.

Basic Information

Product Name	6Alpha,9-Difluoro-11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate
CAS No.	2326-26-3
Molecular Formula	C23H26F2O6
Molecular Weight	436.45 g/mol
Synonyms	Difluprednate Intermediate; 6α,9α-Difluoro-11β,21-dihydroxy-1,4,16-pregnatriene-3,20-dione 21-acetate; 9α-Fluoro-11β,21-dihydroxy-16-methyleneprednisolone 21-acetate; 16-Methylene-6α,9α-difluoroprednisolone 21-acetate; 6α,9α-Difluoro-16-methyleneprednisolone 21-acetate; 21-Acetoxy-6α,9α-difluoro-11β-hydroxy-16-methyleneprednisone; NSC 134455
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing HPLC assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.