Description

16-Methylhydrocortisone is a synthetic corticosteroid derivative, a methylated analog of hydrocortisone. This modification enhances its metabolic stability and alters its pharmacological profile, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by R&D laboratories and manufacturers in the pharmaceutical and life sciences sectors for the synthesis of novel steroid-based therapeutics and for detailed metabolic studies.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of novel corticosteroid drugs and anti-inflammatory agents.
• Biochemical Research: Used as a reference standard or probe in metabolic pathway studies and steroid hormone receptor research.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at developing new glucocorticoid receptor modulators.
• Analytical Standard: Employed as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.

Basic Information

Product Name	16-Methylhydrocortisone
CAS No.	2294-17-9
Molecular Formula	C₂₂H₃₂O₅
Molecular Weight	376.49 g/mol
Synonyms	16α-Methylhydrocortisone; 16α-Methylcortisol; 11β,17α,21-Trihydroxy-16α-methylpregn-4-ene-3,20-dione; 16-Methylcortisol; 16α-Methyl-11β,17α,21-trihydroxypregn-4-ene-3,20-dione
EINECS	Contact for details

Quality Control

Our 16-Methylhydrocortisone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, IR and NMR for identification, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to ensure compliance with your research and manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.