Description

Dexamethasone 21-Methanesulfonate is a key pharmaceutical intermediate and a chemically modified derivative of the potent glucocorticoid dexamethasone. This compound is crucial for the synthesis of more complex steroid-based therapeutics, offering enhanced solubility and reactivity profiles for targeted drug development. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the production of anti-inflammatory, immunosuppressive, and oncological treatments.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced corticosteroid drugs and prodrugs.
• Anti-inflammatory Drug Research: Used in R&D for developing novel, high-potency glucocorticoid receptor agonists.
• Prodrug Synthesis: Serves as a precursor for creating water-soluble or site-specific dexamethasone prodrugs to improve bioavailability.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Biochemical Research: Utilized in studies investigating steroid hormone action, gene expression, and cellular signaling pathways.
• Veterinary Medicine: Applied in the development of anti-inflammatory treatments for animal healthcare.

Basic Information

Product Name	Dexamethasone 21-Methanesulfonate
CAS No.	2265-22-7
Molecular Formula	C23H31FO7S
Molecular Weight	470.55 g/mol
Synonyms	Dexamethasone 21-Mesylate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-methanesulfonate; Dexamethasone Methanesulfonate Ester; Dexamethasone 21-(Methylsulfonate); 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-methanesulfonate
EINECS	Contact for details

Quality Control

Our Dexamethasone 21-Methanesulfonate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.