Description

Pregnane-3,20-Dione, 9-Fluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Dipotassium Salt, (5Alpha,11Beta,16Alpha)- is a high-purity, water-soluble corticosteroid derivative, specifically a dipotassium phosphate ester. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity, enabling the development of advanced topical and injectable steroid formulations. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in steroid-based therapeutics, dermatological products, and ophthalmic solutions.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of potent topical corticosteroids (e.g., derivatives of fluocinolone acetonide).
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of steroid APIs for anti-inflammatory and immunosuppressive medications.
• Dermatological Research: Employed in R&D for developing new creams, ointments, and gels for treating psoriasis, eczema, and dermatitis.
• Ophthalmic Solution Development: Investigated for use in eye drops to treat inflammatory eye conditions such as uveitis.
• Veterinary Pharmaceutical Synthesis: Utilized in creating anti-inflammatory treatments for animals.
• Biochemical Research: Serves as a reference standard or probe in studying glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	Pregnane-3,20-Dione, 9-Fluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Dipotassium Salt, (5Alpha,11Beta,16Alpha)-
CAS No.	2260-24-4
Molecular Formula	C24H31FO9P · 2K
Molecular Weight	584.58 g/mol
Synonyms	9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-(dihydrogen phosphate) dipotassium salt; Fluocinolone Acetonide Phosphate, Dipotassium Salt; Fluocinolone Acetonide 21-Phosphate, Dipotassium Salt; 21-Phosphonooxy-9-fluoro-11β-hydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione dipotassium salt; SQ-16360; NSC-101791; Flucinolone Acetonide Phosphate (Dipotassium)
EINECS	Contact for details

Quality Control

Our Pregnane-3,20-Dione derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and related substances, to ensure it meets exacting standards suitable for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided with every shipment. We can support development with material compliant to ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.