Description

Sodium Difluoroacetate is a versatile organofluorine building block and reagent of significant commercial interest. Its value lies in the introduction of the difluoromethyl group, a key motif in modern pharmaceuticals and agrochemicals that can modulate metabolic stability and lipophilicity. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, serving as a critical precursor for the synthesis of active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethyl ether or difluoromethyl groups to enhance drug properties.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluoroacetate moiety contributes to efficacy and environmental profile.
• Fluorinated Material Production: Serves as a building block for creating specialty polymers, liquid crystals, and electronic materials that require specific fluorine content.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and coupling reactions to introduce the -CF2COO- group into complex organic molecules.
• Biochemical Research: Utilized in metabolic studies and as a tool compound in medicinal chemistry research for probing enzyme interactions.
• Chemical Intermediate for Fluorinated Surfactants: Acts as a starting material for producing fluorinated surfactants and surface treatment agents.

Basic Information

Item	Detail
Product Name	Sodium Difluoroacetate
CAS No.	2218-52-2
Molecular Formula	C2HF2NaO2
Molecular Weight	118.01 g/mol
Synonyms	Sodium 2,2-Difluoroacetate; Difluoroacetic Acid Sodium Salt; 2,2-Difluoroacetic Acid Sodium Salt; Sodium 2,2-Difluoroethanoate; DFA Sodium Salt; NaDFA; Sodium α,α-Difluoroacetate
EINECS	218-727-8

Quality Control

Our Sodium Difluoroacetate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including assay by titration, identification by FT-IR, and determination of key impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your specific project requirements and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (Titration)	≥ 98.0 %
Water Content (KF)	≤ 2.0 %
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.