Description

Prednisolone 21-Ethylcarbonate is a synthetic corticosteroid derivative, specifically a prodrug ester of prednisolone. This compound is valued for its enhanced stability and modified pharmacokinetic profile compared to the parent steroid, offering controlled release characteristics. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of advanced corticosteroid formulations.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of more complex corticosteroid APIs (Active Pharmaceutical Ingredients).
• Prodrug Development: Used in research to create prodrugs with improved lipophilicity, absorption, or targeted delivery for anti-inflammatory and immunosuppressive therapies.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or other chromatographic methods.
• Veterinary Medicine: Employed in the formulation of long-acting injectable or topical treatments for inflammatory conditions in animals.
• Biochemical Research: Used in preclinical studies to investigate glucocorticoid receptor activity, metabolism, and esterase-mediated activation pathways.
• Dermatological Preparations: A potential ingredient in the development of topical creams or ointments for treating skin inflammation and allergies.

Basic Information

Product Name	Prednisolone 21-Ethylcarbonate
CAS No.	2205-88-1
Molecular Formula	C₂₄H₃₂O₇
Molecular Weight	432.51 g/mol
Synonyms	Prednisolone 21-(Ethyl Carbonate); 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-Ethyl Carbonate; Ethyl Prednisolone-21-carbonate; NSC 106977; Prednisolone Ethylcarbonate; 21-Ethoxycarbonyloxyprednisolone; δ1-Cortisone 21-Ethyl Carbonate
EINECS	218-635-9

Quality Control

Our Prednisolone 21-Ethylcarbonate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent specifications for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.