Description

Hydrocortisone 21-Hemisuccinate is a key pharmaceutical intermediate and prodrug form of the natural glucocorticoid hydrocortisone. This compound is essential for enhancing the water solubility and bioavailability of hydrocortisone, facilitating its formulation into injectable and topical medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of corticosteroid-based therapies, including anti-inflammatory, anti-allergy, and immunosuppressive treatments.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of high-potency corticosteroid APIs (Active Pharmaceutical Ingredients).
• Injectable Formulations: Used to produce water-soluble salts (e.g., hydrocortisone sodium succinate) for emergency intravenous administration in cases of adrenal insufficiency and severe allergic reactions.
• Topical Preparations: Incorporated into creams, ointments, and lotions for treating inflammatory skin conditions like eczema, psoriasis, and dermatitis.
• Ophthalmic Solutions: A component in eye drops and ointments for managing ocular inflammation and allergies.
• Research & Development: Serves as a standard and building block in biochemical research, drug discovery, and metabolic studies.
• Veterinary Medicine: Employed in anti-inflammatory and immunosuppressive treatments for animals.

Basic Information

Product Name	Hydrocortisone 21-Hemisuccinate
CAS No.	2203-97-6
Molecular Formula	C25H34O8
Molecular Weight	462.53 g/mol
Synonyms	Hydrocortisone 21-hemisuccinate; Hydrocortisone 21-(hydrogen succinate); 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-hemisuccinate; Cortisol 21-hemisuccinate; Hydrocortisone hemisuccinate; NSC 10483; Hydrocortisone 21-succinate; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-(3-carboxy-1-oxopropoxy)-
EINECS	218-630-9

Quality Control

Our Hydrocortisone 21-Hemisuccinate is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure compliance with relevant pharmaceutical standards, including identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.