Description

Hydroxyzine Dihydrochloride CAS NO 2192-20-3 is a high-purity pharmaceutical active ingredient, a dihydrochloride salt of the first-generation antihistamine hydroxyzine. This compound is a critical intermediate and active pharmaceutical ingredient (API) valued for its reliable quality and consistent performance in finished dosage forms. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of therapeutic agents for anxiety, pruritus, and as a premedication.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the management of anxiety and tension.
• Antipruritic Formulations: Key component in topical and systemic treatments for relieving itching associated with allergic conditions, such as chronic urticaria and atopic dermatitis.
• Preoperative Sedation: Used in the formulation of pre-anesthetic medication to produce sedation and reduce anxiety before surgery.
• Antiemetic Adjunct: Employed as an adjunct therapy to control nausea and vomiting, particularly in postoperative settings.
• Research & Development: Serves as a reference standard and building block in pharmacological research, metabolism studies, and analytical method development.
• Generic Drug Manufacturing: Essential for companies producing generic versions of branded hydroxyzine dihydrochloride tablets and syrups.

Basic Information

Product Name	Hydroxyzine Dihydrochloride
CAS No.	2192-20-3
Molecular Formula	C21H31Cl3N2O2
Molecular Weight	447.84 g/mol
Synonyms	Hydroxyzine HCl; Hydroxyzine Hydrochloride; 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol Dihydrochloride; Atarax (brand name); Vistaril (brand name); (±)-Hydroxyzine Dihydrochloride; 1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine Dihydrochloride
EINECS	218-593-8

Quality Control

Our Hydroxyzine Dihydrochloride is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (KF Titration)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.