Description

Betamethasone 17-Valerate is a potent synthetic corticosteroid ester widely used in pharmaceutical formulations. This compound is valued for its enhanced topical anti-inflammatory and antipruritic activity compared to its parent molecule. It is a critical active pharmaceutical ingredient (API) for manufacturers developing dermatological treatments. Primary industrial demand comes from the pharmaceutical sector for producing creams, ointments, and lotions.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in topical corticosteroid preparations.
• Formulation of prescription-strength creams and ointments for treating inflammatory skin conditions like eczema, psoriasis, and dermatitis.
• Manufacture of medicated lotions for scalp applications and other dermatoses.
• Key intermediate in the synthesis of more complex steroid-based pharmaceutical compounds.
• Used in veterinary medicine for topical anti-inflammatory applications.
• Research and development of novel drug delivery systems for enhanced dermal penetration.

Basic Information

Product Name	Betamethasone 17-Valerate
CAS No.	2152-44-5
Molecular Formula	C27H37FO6
Molecular Weight	476.58 g/mol
Synonyms	Betamethasone Valerate; Betnovate; Celestoderm-V; Valisone; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate; (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-pentanoate
EINECS	218-441-8

Quality Control

Our Betamethasone 17-Valerate is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. It is typically produced to comply with pharmacopeial specifications such as USP, EP, or BP. Each batch undergoes comprehensive analytical testing including assay, related substances, and residual solvent analysis. A Certificate of Analysis (COA) documenting full compliance is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	+75° to +82° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.