Description

Pregna-1,4-Diene-3,20-Dione, 6-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, Disodium Salt, (6Alpha,11Beta,16Alpha)- is a high-purity synthetic corticosteroid derivative, specifically a phosphorylated and fluorinated glucocorticoid. This compound is of significant value as a key pharmaceutical intermediate or reference standard in advanced steroid synthesis and research. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and analytical service providers engaged in developing novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced corticosteroid drugs and prodrugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor (GR) activity, metabolism, and signal transduction pathways.
• Prodrug Development: The phosphorylated disodium salt form is explored for enhancing solubility and bioavailability in drug formulation.
• Metabolite Studies: Utilized as a standard or starting material for the synthesis and identification of steroid metabolites.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 6-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, Disodium Salt, (6Alpha,11Beta,16Alpha)-
CAS No.	2145-14-4
Molecular Formula	C22H27FNa2O8P
Molecular Weight	530.39 g/mol
Synonyms	6α-Fluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(Disodium Phosphate); 6α-Fluoroprednisolone 21-Phosphate Disodium Salt; Fluprednisolone 21-Phosphate Disodium Salt; Fluprednisolone Sodium Phosphate; U-7532; NSC-47439; Fluprednisolone 21-(Disodium Phosphate)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development purposes, with typical purity levels meeting or exceeding 95% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and related substances are available upon request. Specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.