Description

Prednisolone 21-Formate is a synthetic corticosteroid derivative, specifically a formate ester of prednisolone. This compound is a key pharmaceutical intermediate valued for its role in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development and production of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced corticosteroid drugs.
• Anti-inflammatory Drug Research: Used in R&D for creating novel therapeutic agents targeting inflammation pathways.
• Immunosuppressant Development: Serves as a precursor in the manufacture of medications used to manage autoimmune diseases and prevent organ transplant rejection.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Used in academic and industrial research to study steroid metabolism and receptor interactions.
• Veterinary Pharmaceutical Synthesis: A component in the production of corticosteroid treatments for animal health.

Basic Information

Product Name	Prednisolone 21-Formate
CAS No.	2141-22-2
Molecular Formula	C22H28O6
Molecular Weight	388.46 g/mol
Synonyms	Prednisolone 21-formate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-formate; Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, 21-formate, (11β)-; 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-formate; NSC 52907; δ1-Hydrocortisone 21-formate; Formic acid, (11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-ester
EINECS	Contact for details

Quality Control

Our Prednisolone 21-Formate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light and moisture to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.