Description

9Beta,11Beta-Epoxy-6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is a high-purity synthetic steroid intermediate, specifically a fluorinated and pivalate-esterified derivative of pregnadiene. This compound matters as a critical building block in the pharmaceutical synthesis of potent topical corticosteroids, offering a pathway to enhanced anti-inflammatory activity and metabolic stability. It is primarily needed by advanced pharmaceutical R&D laboratories and API (Active Pharmaceutical Ingredient) manufacturers focused on developing next-generation dermatological and anti-inflammatory therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of advanced topical corticosteroid APIs, such as fluticasone propionate and related analogues.
• Steroid Research & Development: Used in medicinal chemistry programs to study structure-activity relationships (SAR) of fluorinated steroids.
• Process Chemistry: Serves as a defined intermediate for scale-up and optimization of GMP (Good Manufacturing Practice) manufacturing processes for steroid-based drugs.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of related steroid compounds.

Basic Information

Product Name	9Beta,11Beta-Epoxy-6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate
CAS No.	2135-16-2
Molecular Formula	C₂₉H₃₇FO₆
Molecular Weight	488.60 g/mol
Synonyms	Fluticasone Propionate EP Impurity C; 6α-Fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-17-yl 2,2-dimethylpropanoate 9,11-epoxide; 9β,11β-Epoxy-6α-fluoro-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate; 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione cyclic 9,11-hemiacetal with pivalic acid 21-ester; SBM 1; Fluticasone Propionate Related Compound C; 17-[(2,2-Dimethyl-1-oxopropoxy)methyl]-6,9-difluoro-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid γ-lactone (incorrect but common alias).
EINECS	Contact for details

Quality Control

Our 9Beta,11Beta-Epoxy-6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure compliance with stringent in-house specifications suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.