Description

3-Chloro-2-Fluoronitrobenzene is a versatile halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for the development of complex molecules, particularly in the agrochemical and pharmaceutical sectors. This intermediate is essential for researchers and manufacturers creating active ingredients, dyes, and functional materials, where precise halogen positioning is required for desired reactivity and properties.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the reactivity of the nitro and halogen groups.
• Pharmaceutical Building Block: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated and chlorinated aromatic core.
• Dye and Pigment Synthesis: Serves as an intermediate in the production of specialized dyes and organic pigments, where the nitro group facilitates further chemical transformations.
• Material Science Research: Employed in the synthesis of liquid crystals, organic semiconductors, and other functional materials that benefit from its specific electronic properties.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it suitable for reactions with amines, alkoxides, and other nucleophiles.

Basic Information

Product Name	3-Chloro-2-Fluoronitrobenzene
CAS No.	2106-49-2
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-2-fluoro-3-nitrobenzene; 2-Fluoro-3-chloronitrobenzene; 3-Chloro-2-fluoro-1-nitrobenzene; 3-Chloro-2-fluoronitrobenzene; 2-Fluoro-3-chloro-1-nitrobenzene; Benzene, 1-chloro-2-fluoro-3-nitro-; o-Fluoro-m-chloronitrobenzene; 3-Chloro-2-fluoronitrobenzene (CAS 2106-49-2)
EINECS	218-277-6

Quality Control

Our 3-Chloro-2-Fluoronitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.