Description

1,2,4-Trifluoro-5-Nitrobenzene CAS NO 2105-61-5 is a high-purity fluorinated aromatic nitro compound, serving as a critical building block in advanced organic synthesis. Its unique trifluoro-nitro substitution pattern makes it an indispensable intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing fluorinated aromatic rings, such as certain antibiotics and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity, stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, lower dielectric constants, or enhanced weatherability.
• Dye & Pigment Intermediate: Utilized in the production of advanced colorants and fluorescent dyes for high-performance applications.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluorine groups make it an excellent substrate for nucleophilic substitution reactions, enabling the introduction of various heteroatoms and functional groups.
• Academic & Contract Research: A valuable reagent for methodological development and discovery chemistry in academic and industrial research laboratories.

Basic Information

Product Name	1,2,4-Trifluoro-5-Nitrobenzene
CAS No.	2105-61-5
Molecular Formula	C6H2F3NO2
Molecular Weight	177.08 g/mol
Synonyms	5-Nitro-1,2,4-trifluorobenzene; 1,2,4-Trifluoro-5-nitrobenzene; 2,4,5-Trifluoronitrobenzene; Benzene, 1,2,4-trifluoro-5-nitro-; NSC 404087; 5-Nitro-1,2,4-trifluorobenzol; 2,4,5-Trifluoro-1-nitrobenzene
EINECS	218-267-5

Quality Control

Our 1,2,4-Trifluoro-5-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment ensures batch-to-batch consistency and traceability for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.