Description

16α-Methyl-11-Oxo Prednisolone is a synthetic corticosteroid derivative, a key intermediate in the pharmaceutical synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). Its value lies in providing a structurally defined, high-purity building block that enables precise chemical modifications for research and manufacturing. This compound is essential for pharmaceutical R&D laboratories and API manufacturers focused on developing novel anti-inflammatory, immunosuppressive, and dermatological treatments.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the multi-step synthesis of advanced corticosteroid APIs.
• Research & Development: Serves as a standard or starting material in medicinal chemistry for structure-activity relationship (SAR) studies of steroid analogs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing via HPLC or LC-MS.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for steroid production under cGMP conditions.
• Biochemical Research: Investigated for its interaction with glucocorticoid receptors to study metabolic and immune response pathways.

Basic Information

Product Name	16α-Methyl-11-Oxo Prednisolone
CAS No.	2036-77-3
Molecular Formula	C₂₂H₂₈O₅
Molecular Weight	372.46 g/mol
Synonyms	16α-Methyl-11-oxoprednisolone; 16α-Methylprednisolone-11-one; 11-Oxo-16α-methylprednisolone; 9α-Fluoro-16α-methyl-11-oxoprednisolone (common misnomer); 16α-Methyl-11-ketoprednisolone; (11β)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione; δ¹,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 16α-methyl-
EINECS	Contact for details

Quality Control

Our 16α-Methyl-11-Oxo Prednisolone is manufactured and tested to meet stringent quality standards suitable for pharmaceutical research and development. We provide comprehensive quality assurance, with typical purity levels exceeding 98% (by HPLC). Each batch is accompanied by a detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles. Our quality system supports compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.