Description

2,2-Difluoro-2-Phenylacetonitrile is a versatile fluorinated organic building block characterized by its reactive nitrile and difluoromethylene groups. This compound is critical for introducing the difluoromethyl moiety into complex molecules, a key strategy in modern medicinal and agrochemical chemistry for modulating lipophilicity, metabolic stability, and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of difluoromethylated analogs in drug discovery, particularly for kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the difluoromethyl group enhances biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic displays and organic light-emitting diodes to improve performance and stability.
• Fluorine Chemistry Research: An essential reagent for studying nucleophilic substitution and addition reactions involving gem-difluorinated centers in academic and industrial R&D settings.

Basic Information

Product Name	2,2-Difluoro-2-Phenylacetonitrile
CAS No.	2002-72-4
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	α,α-Difluorophenylacetonitrile; 2,2-Difluoro-2-phenylethanenitrile; (Difluoromethyl)benzonitrile; Benzylidene difluoride, cyano-; Phenyl(difluoro)acetonitrile; Difluorophenylacetonitrile; 2-Phenyl-2,2-difluoroacetonitrile; α-Cyano-α,α-difluorotoluene
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing specific results for purity, water content, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential contamination. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.