Description

Flumethasone 21-Pivalate is a synthetic corticosteroid ester, specifically the 21-pivalate derivative of flumethasone. This compound is valued for its potent anti-inflammatory and glucocorticoid activity, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by manufacturers in the pharmaceutical and veterinary medicine sectors for the development of topical and injectable corticosteroid formulations.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of potent topical corticosteroid APIs (Active Pharmaceutical Ingredients).
• Veterinary Medicine: Used in the formulation of anti-inflammatory and anti-pruritic treatments for dermatological conditions in animals.
• Research & Development: Serves as a reference standard and building block in medicinal chemistry research for novel glucocorticoid receptor agonists.
• Dermatological Preparations: A precursor for APIs used in creams, ointments, and lotions for treating eczema, psoriasis, and other inflammatory skin disorders.
• Steroid Prodrug Development: Utilized in creating prodrugs with enhanced dermal penetration or modified release profiles.

Basic Information

Product Name	Flumethasone 21-Pivalate
CAS No.	2002-29-1
Molecular Formula	C27H36F2O6
Molecular Weight	494.57 g/mol
Synonyms	Flumethasone Pivalate; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Pivalate; 21-(2,2-Dimethylpropanoyloxy)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; Flumethasone 21-Trimethylacetate; NSC 121154; SQ 15102; Flumetasone Pivalate
EINECS	Contact for details

Quality Control

Our Flumethasone 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and control of specific impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.