Description

5-α-Dihydrocorticosterone is a key synthetic corticosteroid intermediate with significant biological activity. This compound is essential for research and development in the pharmaceutical sector, particularly in the study of steroid hormone metabolism and the synthesis of more complex therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for anti-inflammatory and hormonal therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of advanced corticosteroid drugs and other steroid-based pharmaceuticals.
• Biochemical Research: Used as a reference standard and experimental compound in studies investigating steroidogenesis, enzyme inhibition (e.g., 5-α-reductase), and glucocorticoid receptor interactions.
• Metabolite Standard: Serves as an analytical standard in laboratories for the quantification of steroid metabolites in biological samples via HPLC or LC-MS/MS.
• API Development: Employed in the research and process development of novel anti-inflammatory and immunosuppressive agents.

Basic Information

Product Name	5-α-Dihydrocorticosterone
CAS No.	298-25-9
Molecular Formula	C21H30O4
Molecular Weight	346.46 g/mol
Synonyms	5α-Dihydrocorticosterone; 11β,21-Dihydroxy-5α-pregnane-3,20-dione; 5α-Pregnane-11β,21-diol-3,20-dione; Dihydrocorticosterone; 5α-DHC; 11β,21-Dihydroxy-5α-pregnan-3,20-dione; 5α-Pregnan-11β,21-diol-3,20-dione
EINECS	206-074-1

Quality Control

Our 5-α-Dihydrocorticosterone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.