Description

4-(Difluoromethyl)-3-Nitrobenzonitrile is a versatile aromatic nitrile building block featuring both difluoromethyl and nitro substituents, offering unique electronic and steric properties for advanced synthesis. This compound is critical for medicinal chemistry and agrochemical research, where its structure serves as a key intermediate for introducing fluorinated motifs into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly for kinase inhibitors and CNS-active compounds.
• Agrochemical Research: Used in developing novel herbicides and pesticides where the difluoromethyl group enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a building block for fluorinated liquid crystals, polymers, and organic electronic materials.
• Chemical Biology Probes: Utilized in creating fluorinated tags and probes for studying enzyme mechanisms and protein interactions.
• Cross-Coupling Reactions: The nitrile and nitro groups make it a suitable substrate for palladium-catalyzed cross-coupling and nucleophilic aromatic substitution reactions.
• Fluorine Chemistry Library Synthesis: An essential component for constructing diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	4-(Difluoromethyl)-3-Nitrobenzonitrile
CAS No.	1956334-79-4
Molecular Formula	C8H4F2N2O2
Molecular Weight	198.13 g/mol
Synonyms	3-Nitro-4-(difluoromethyl)benzonitrile; 4-(Difluoromethyl)-3-nitrobenzonitrile; Benzonitrile, 4-(difluoromethyl)-3-nitro-; 1956334-79-4; 4-Difluoromethyl-3-nitro-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-3-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.