Description

2-Amino-4-Bromo-5-Fluorobenzonitrile is a high-purity, multi-functional halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring amino, bromo, fluoro, and nitrile functional groups, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogen and nitrile groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes, enzyme inhibitors, and labeled compounds for biochemical assays.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, tailor-made molecules for clients.

Basic Information

Product Name	2-Amino-4-Bromo-5-Fluorobenzonitrile
CAS No.	1935427-48-7
Molecular Formula	C7H4BrFN2
Molecular Weight	215.03 g/mol
Synonyms	4-Bromo-5-fluoro-2-aminobenzonitrile; 5-Fluoro-2-amino-4-bromobenzonitrile; 2-Amino-4-bromo-5-fluorobenzene carbonitrile; Benzonitrile, 2-amino-4-bromo-5-fluoro-; 4-Bromo-5-fluoroanthranilonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4-Bromo-5-Fluorobenzonitrile is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.