Description

tert-Butyl (1-(Fluoromethyl)Cyclopropyl)Carbamate is a specialized carbamate-protected amine building block featuring a cyclopropane ring and a fluoromethyl substituent. This compound is valued for its role as a key synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by research and development teams in pharmaceutical, agrochemical, and fine chemical synthesis who require high-purity, structurally complex intermediates for lead optimization and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluoromethyl and cyclopropyl groups can impart desirable biological activity.
• Peptide Mimetics & PROTACs: Serves as a protected amine component in the construction of peptide analogs and Proteolysis Targeting Chimeras (PROTACs).
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and target engagement.
• Material Science Research: Potential monomer or precursor for developing specialty polymers with unique properties derived from the strained cyclopropane ring.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific molecular scaffold.

Basic Information

Product Name	tert-Butyl (1-(Fluoromethyl)Cyclopropyl)Carbamate
CAS No.	1935385-93-5
Molecular Formula	C9H16FNO2
Molecular Weight	189.23 g/mol
Synonyms	1-(Fluoromethyl)cyclopropanamine, N-Boc derivative; Boc-1-(fluoromethyl)cyclopropylamine; tert-Butyl N-[1-(fluoromethyl)cyclopropyl]carbamate; 1-(Fluoromethyl)cyclopropylcarbamic acid tert-butyl ester; (1-(Fluoromethyl)cyclopropyl)carbamic acid tert-butyl ester; N-Boc-1-(fluoromethyl)cyclopropanamine; BOC-1-(Fluoromethyl)cyclopropylamine
EINECS	Contact for details

Quality Control

Our tert-Butyl (1-(Fluoromethyl)Cyclopropyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for advanced intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.