Description

trans-1-Cbz-4-Fluoro-3-Hydroxypiperidine is a high-purity, fluorinated piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a protected amine (Cbz), a fluorine substituent, and a hydroxyl group, makes it an invaluable intermediate for constructing complex, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel drug candidates, enzyme inhibitors, and other fine chemicals where precise stereochemistry and fluorination are required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery programs.
• Protease Inhibitor Synthesis: Used in the construction of scaffolds for protease inhibitors, leveraging the fluorine atom for metabolic stability and the hydroxyl group for hydrogen bonding.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides, where the fluorine moiety can enhance bioavailability and environmental persistence.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and combinatorial chemistry to explore new chemical spaces and optimize lead compounds.
• Peptidomimetics: Integral for creating peptidomimetic compounds that mimic natural peptides but with improved stability and pharmacological properties.
• Chemical Biology Probes: Used to synthesize labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	trans-1-Cbz-4-Fluoro-3-Hydroxypiperidine
CAS No.	1932006-50-2
Molecular Formula	C13H16FNO3
Molecular Weight	253.27 g/mol
Synonyms	trans-1-[(Benzyloxy)carbonyl]-4-fluoro-3-hydroxypiperidine; (3R,4S)-1-[(Benzyloxy)carbonyl]-4-fluoro-3-hydroxypiperidine; (3S,4R)-1-[(Benzyloxy)carbonyl]-4-fluoro-3-hydroxypiperidine; 1-Cbz-4-fluoro-3-hydroxypiperidine (trans); 4-Fluoro-3-hydroxy-1-N-Cbz-piperidine; 1-N-Carbobenzoxy-4-fluoro-3-hydroxypiperidine; Benzyl (3R,4S)-4-fluoro-3-hydroxypiperidine-1-carboxylate; Benzyl (3S,4R)-4-fluoro-3-hydroxypiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our trans-1-Cbz-4-Fluoro-3-Hydroxypiperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.