Description

(Des-Gly10,D-Trp6,D-Leu7,Pro-Nhet9)-Lhrh CAS NO 1926163-24-7 is a synthetic peptide analog of Luteinizing Hormone-Releasing Hormone (LHRH), engineered with specific D-amino acid substitutions and a modified C-terminus. This structural modification is critical for enhancing metabolic stability and receptor binding affinity, making it a valuable tool in advanced endocrinology research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroendocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel LHRH-based therapeutics.
• Endocrinology Studies: Used in vitro and in vivo to study the structure-activity relationship (SAR) of LHRH analogs and their interaction with gonadotropin-releasing hormone (GnRH) receptors.
• Oncology Research: Investigated for applications in hormone-dependent cancers, such as prostate and breast cancer, due to its potential to modulate hormonal pathways.
• Reproductive Medicine: Employed in research concerning fertility treatments and the regulation of the hypothalamic-pituitary-gonadal axis.
• Biochemical Assay Development: Acts as a critical component in the development and validation of high-throughput screening (HTS) assays and diagnostic kits.
• Peptide Chemistry & Conjugation: Provides a sophisticated scaffold for further chemical modification, labeling, or conjugation in drug delivery system development.

Basic Information

Item	Detail
Product Name	(Des-Gly10,D-Trp6,D-Leu7,Pro-Nhet9)-Lhrh
CAS No.	1926163-24-7
Molecular Formula	C58H78N16O12
Molecular Weight	1151.3 g/mol
Synonyms	D-Trp6, D-Leu7, Pro-NHEt9-LHRH; GnRH Antagonist Analog; LHRH Antagonist (Des-Gly10); pGlu-His-Trp-Ser-Tyr-D-Trp-D-Leu-Arg-Pro-NHEt; Gonadorelin (6-D-Trp, 7-D-Leu, 9-Pro-NHEt) analog; Luteinizing Hormone-Releasing Hormone Antagonist; 1926163-24-7; LHRH Analog
EINECS	Contact for details

Quality Control

Our (Des-Gly10,D-Trp6,D-Leu7,Pro-Nhet9)-Lhrh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.