Description

(S)-4,4-Difluoro-2-Methylpyrrolidine Hydrochloride CAS NO 1917292-38-6 is a high-purity chiral building block and intermediate of significant interest in modern pharmaceutical research and development. Its value lies in the unique structural motif of a fluorinated pyrrolidine, which is increasingly utilized to modulate the physicochemical and metabolic properties of drug candidates. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, agrochemical, and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorinated pyrrolidine structure can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to create enantiomerically pure compounds.
• Peptidomimetics & Bioisosteres: The difluoromethyl group acts as a bioisostere for carbonyl or other functional groups, useful in designing peptide analogs with improved metabolic stability.
• Fluorine Chemistry Library Synthesis: A valuable component for constructing diverse compound libraries aimed at drug discovery screening programs focused on fluorine-containing molecules.
• Material Science Precursor: Potential use in the synthesis of specialty polymers or organic electronic materials where fluorine incorporation can alter material properties.

Basic Information

Product Name	(S)-4,4-Difluoro-2-Methylpyrrolidine Hydrochloride
CAS No.	1917292-38-6
Molecular Formula	C5H10F2N·HCl
Molecular Weight	169.60 g/mol (Free base: 134.14 g/mol)
Synonyms	(S)-2-Methyl-4,4-difluoropyrrolidine hydrochloride; (2S)-2-Methyl-4,4-difluoropyrrolidine hydrochloride; 4,4-Difluoro-2-methylpyrrolidine hydrochloride, (S)-; (S)-4,4-Difluoro-2-methylpyrrolidine HCl; (S)-2-Methyl-4,4-difluoro-pyrrolidine hydrochloride; Pyrrolidine, 4,4-difluoro-2-methyl-, hydrochloride, (2S)-; (S)-2-Methyl-4,4-difluoropyrrolidine HCl salt
EINECS	Contact for details

Quality Control

Our (S)-4,4-Difluoro-2-Methylpyrrolidine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.