Description

Mes-Umemoto Reagent CAS NO 1895006-01-5 is a specialized trifluoromethylation reagent, a key chemical tool for introducing the trifluoromethyl (CF3) group into organic molecules. This reagent is highly valued for its ability to perform radical trifluoromethylation reactions under mild conditions, enabling the synthesis of complex fluorinated compounds. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who are developing new active ingredients with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for the late-stage functionalization of drug candidates, particularly in the development of antiviral, anticancer, and central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used to create novel herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science: Employed in the synthesis of fluorinated polymers, liquid crystals, and electronic materials to modify surface properties, dielectric constants, and chemical resistance.
• Radical Chemistry & Methodology Development: A staple reagent in academic and industrial laboratories for exploring new radical trifluoromethylation pathways and reaction mechanisms.
• PET (Positron Emission Tomography) Tracer Synthesis: Facilitates the incorporation of fluorine-18 or carbon-11 labeled CF3 groups for diagnostic imaging agents.
• Fine Chemical Production: Enables the scalable manufacture of high-value fluorinated building blocks and specialty chemicals.

Basic Information

Product Name	Mes-Umemoto Reagent
CAS No.	1895006-01-5
Molecular Formula	C10H10F3NO4S
Molecular Weight	297.25 g/mol
Synonyms	1-Mesityl-2,2,2-trifluoroethan-1-one; (Mesityl)(trifluoroacetyl)oxime; Mesityl Trifluoromethyl Ketone O-Mesitylenesulfonyloxime; Mesityl(trifluoroacetyl)oxime O-Mesitylenesulfonate; Trifluoromethyl Mesitylene Sulfonyl Oxime; Umemoto Reagent; Mes-Umemoto's Reagent; Togni Reagent Alternative (Type II)
EINECS	Contact for details

Quality Control

Our Mes-Umemoto Reagent is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including HPLC for purity and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, containers should be sealed under an inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent decomposition. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.