Description

1-Chloro-5-Fluoro-2-Methoxy-3-Nitrobenzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Serves as a core building block for developing new herbicides, fungicides, and insecticides, leveraging the fluorine and nitro groups for enhanced bioactivity and environmental stability.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro group and halogen substituents.
• Dye and Pigment Intermediate: Employed in the synthesis of complex azo dyes and high-performance pigments where the methoxy and nitro groups influence color and fastness properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification in medicinal chemistry libraries.

Basic Information

Product Name	1-Chloro-5-Fluoro-2-Methoxy-3-Nitrobenzene
CAS No.	1881329-08-3
Molecular Formula	C7H5ClFNO3
Molecular Weight	205.57 g/mol
Synonyms	3-Nitro-2-methoxy-5-fluoro-1-chlorobenzene; 2-Chloro-4-fluoro-5-nitroanisole; 5-Fluoro-2-methoxy-3-nitrochlorobenzene; 1-Chloro-5-fluoro-2-methoxy-3-nitrobenzene; 2-Methoxy-5-fluoro-3-nitrochlorobenzene; 4-Fluoro-5-nitro-2-chloroanisole; Benzene, 1-chloro-5-fluoro-2-methoxy-3-nitro-
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Fluoro-2-Methoxy-3-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive; prolonged exposure to light should be avoided to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.