Description

6-Chloro-2,4-Difluoro-3-Methylphenylacetonitrile is a high-value, multi-functional aromatic nitrile building block designed for advanced chemical synthesis. Its molecular structure, featuring chloro, fluoro, and methyl substituents on the phenyl ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules with fluorine-containing bioactive cores.
• Agrochemical Synthesis: Serves as a versatile precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the stability and reactivity of the difluorophenyl moiety.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic nitrile functionality.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, cyano-group transformations, and as a scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	6-Chloro-2,4-Difluoro-3-Methylphenylacetonitrile
CAS No.	1858250-05-1
Molecular Formula	C9H6ClF2N
Molecular Weight	201.60 g/mol
Synonyms	2-(6-Chloro-2,4-difluoro-3-methylphenyl)acetonitrile; (6-Chloro-2,4-difluoro-3-methylphenyl)acetonitrile; 6-Chloro-2,4-difluoro-3-methylbenzyl cyanide; 1858250-05-1; Acetonitrile, (6-chloro-2,4-difluoro-3-methylphenyl)-; 2-(6-Chloro-2,4-difluoro-3-methylphenyl)ethanenitrile
EINECS	Contact for details

Quality Control

Our production of 6-Chloro-2,4-Difluoro-3-Methylphenylacetonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting all test results are provided with every shipment. We operate under a cGMP-compliant quality system, and our facilities are ISO-certified, ensuring our products meet the exacting standards of global pharmaceutical and agrochemical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.