Description

5-Bromo-4-Chloro-2-Fluoro-Benzonitrile is a high-purity, multi-halogenated benzonitrile derivative serving as a critical building block in advanced organic synthesis. This compound matters for its precise molecular architecture, enabling the introduction of specific halogen functionalities into complex target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogen-substituted aromatic cores.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the halogen pattern influences biological activity and selectivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Organic Electronic Materials: Employed in the research and development of organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: An excellent substrate for Buchwald-Hartwig amination, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions due to the bromo and chloro leaving groups.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	5-Bromo-4-Chloro-2-Fluoro-Benzonitrile
CAS No.	1824089-00-0
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	2-Fluoro-5-bromo-4-chlorobenzonitrile; 4-Chloro-5-bromo-2-fluorobenzonitrile; Benzonitrile, 5-bromo-4-chloro-2-fluoro-; 5-Bromo-4-chloro-2-fluorobenzonitrile; 1824089-00-0; BCFBN
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-4-Chloro-2-Fluoro-Benzonitrile is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets typical research and development specifications, with Certificates of Analysis (COA) documenting identity, purity, and impurity profiles available for each lot. We support custom synthesis projects with tailored purity requirements and full analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC Area %)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.