Description

5-Amino-4-Fluoro-2-Methyl-Benzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique molecular structure, featuring amino, fluoro, and nitrile substituents on a methylated benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom and nitrile group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as dyes, pigments, and polymers with specific electronic or optical properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags used in biochemical and diagnostic research.

Basic Information

Product Name	5-Amino-4-Fluoro-2-Methyl-Benzonitrile
CAS No.	1824053-65-7
Molecular Formula	C8H7FN2
Molecular Weight	150.16 g/mol
Synonyms	4-Fluoro-5-amino-2-methylbenzonitrile; 2-Methyl-4-fluoro-5-aminobenzonitrile; 5-Amino-4-fluoro-o-tolunitrile; Benzonitrile, 5-amino-4-fluoro-2-methyl-; 4-Fluoro-2-methyl-5-aminobenzonitrile; 2-Methyl-5-amino-4-fluorobenzonitrile; 5-Amino-4-fluoro-2-methylbenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Amino-4-Fluoro-2-Methyl-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.