Description

2-Fluoro-4-Methyl-3-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in polymer chemistry and material science to introduce fluorine atoms into polymers, altering surface properties and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom chemical synthesis services and scale-up production under cGMP or ISO standards.
• Academic & Industrial Research: Utilized in exploratory chemistry to study structure-activity relationships (SAR) and develop novel synthetic methodologies involving fluorinated arenes.

Basic Information

Product Name	2-Fluoro-4-Methyl-3-(Trifluoromethyl)Benzonitrile
CAS No.	1824048-48-7
Molecular Formula	C9H5F4N
Molecular Weight	203.14 g/mol
Synonyms	2-Fluoro-4-methyl-3-(trifluoromethyl)benzonitrile; 3-(Trifluoromethyl)-2-fluoro-4-methylbenzonitrile; 2-Fluoro-α,α,α-trifluoro-4-methyl-m-toluonitrile; 2-Fluoro-4-methyl-3-trifluoromethylbenzonitrile; Benzonitrile, 2-fluoro-4-methyl-3-(trifluoromethyl)-; 1824048-48-7
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methyl-3-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, GC, NMR, and MS, to verify identity and purity. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment aligns with the standards required for pharmaceutical R&D and advanced material synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.