Description

(5,5-Difluorotetrahydropyran-2-Yl)Methanol is a high-value fluorinated building block and chiral intermediate of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine atoms and a functionalized pyran ring, enabling precise modulation of molecular properties for target-oriented applications. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorinated moiety can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, facilitating the production of enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals, where its structure can impart unique solubility and surface properties.
• Medicinal Chemistry Probe: Utilized as a versatile scaffold for structure-activity relationship (SAR) studies to explore new chemical space in drug design.

Basic Information

Product Name	(5,5-Difluorotetrahydropyran-2-Yl)Methanol
CAS No.	1823910-57-1
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	2-(Hydroxymethyl)-5,5-difluorotetrahydropyran; 5,5-Difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran; (5,5-Difluorotetrahydro-2H-pyran-2-yl)methanol; (5,5-Difluorotetrahydropyran-2-yl)methanol; 5,5-Difluorotetrahydropyran-2-ylmethanol; (5,5-Difluorooxan-2-yl)methanol
EINECS	Contact for details

Quality Control

Our (5,5-Difluorotetrahydropyran-2-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.