Description

2-Bromo-3-Chloro-6-Fluorobenzonitrile is a high-purity, multi-halogenated benzonitrile derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable scaffold for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on new active ingredients, where it is used to introduce specific halogen functionalities that can modulate biological activity, metabolic stability, and physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Research: Used to create new herbicides, fungicides, and insecticides where the halogenated aromatic core contributes to binding affinity and environmental stability.
• Material Science: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution for constructing diverse chemical libraries.
• Dye & Pigment Industry: Employed in the synthesis of advanced colorants and fluorescent markers due to its electron-withdrawing nitrile and halogen groups.

Basic Information

Product Name	2-Bromo-3-Chloro-6-Fluorobenzonitrile
CAS No.	1823576-81-3
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	2-Bromo-3-chloro-6-fluorobenzonitrile; 3-Chloro-2-bromo-6-fluorobenzonitrile; 6-Fluoro-3-chloro-2-bromobenzonitrile; Benzonitrile, 2-bromo-3-chloro-6-fluoro-; 2-Bromo-3-chloro-6-fluorophenyl cyanide; 1823576-81-3; BCFBN
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Chloro-6-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.