Description

2-Fluoro-4-Methyl-3-(Trifluoromethyl)Phenylacetonitrile is a high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique trifluoromethyl and fluoro substituents impart desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development teams in the life sciences and specialty chemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Material Research: Building block for novel polymers, coatings, and specialty materials requiring specific dielectric or surface properties.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to introduce complex fluorinated aryl groups.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library development for client projects.

Basic Information

Product Name	2-Fluoro-4-Methyl-3-(Trifluoromethyl)Phenylacetonitrile
CAS No.	1823323-72-3
Molecular Formula	C10H7F4N
Molecular Weight	217.16 g/mol
Synonyms	2-Fluoro-4-methyl-3-(trifluoromethyl)benzyl cyanide; [2-Fluoro-4-methyl-3-(trifluoromethyl)phenyl]acetonitrile; 2-Fluoro-α-tolunitrile, 4-methyl-3-(trifluoromethyl)-; 3-(Trifluoromethyl)-2-fluoro-4-methylphenylacetonitrile; 2-Fluoro-4-methyl-3-trifluoromethylphenylacetonitrile; (2-Fluoro-4-methyl-3-(trifluoromethyl)phenyl)acetonitrile; α-Cyano-2-fluoro-4-methyl-3-(trifluoromethyl)toluene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methyl-3-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.