Description

2,6-Dichloro-4-(trifluoromethoxy)benzonitrile is a high-value, multi-functional aromatic intermediate featuring a nitrile group and halogen substituents. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, enabling the introduction of the trifluoromethoxy moiety which can enhance biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key synthon for the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethoxy group.
• Pharmaceutical Building Block: Used in medicinal chemistry research for the synthesis of drug candidates, particularly in areas targeting central nervous system (CNS) and inflammatory diseases.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced electronic chemicals used in displays and organic light-emitting diodes.
• Specialty Polymer Modification: Employed to introduce halogenated aromatic units into polymer chains to alter thermal stability, flame retardancy, or optical properties.
• Cross-Coupling Reactions: The chlorine atoms make it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new synthetic methodologies and creating novel chemical entities for various applications.

Basic Information

Product Name	2,6-Dichloro-4-(trifluoromethoxy)benzonitrile
CAS No.	1822673-40-4
Molecular Formula	C8H2Cl2F3NO
Molecular Weight	256.01 g/mol
Synonyms	4-Cyano-3,5-dichlorophenyl trifluoromethyl ether; 3,5-Dichloro-4-(trifluoromethoxy)benzonitrile; 2,6-Dichloro-4-(trifluoromethoxy)phenyl cyanide; Benzonitrile, 2,6-dichloro-4-(trifluoromethoxy)-; 4-(Trifluoromethoxy)-3,5-dichlorobenzonitrile
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-4-(trifluoromethoxy)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place. Store under inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.