Description

Fulvestrant (ICI 182780) R Enantiomer is a highly pure, single-enantiomer form of the potent and selective estrogen receptor antagonist. This specific stereoisomer is critical for advanced pharmaceutical research and development, particularly in the study of hormone-dependent conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel endocrine therapies and analytical reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for analytical method development, validation, and quality control (QC/QA) of fulvestrant-based drug substances and products.
• Biochemical Research: Used as a key tool compound in in vitro and in vivo studies to investigate estrogen receptor (ER) signaling pathways, mechanisms of action, and resistance in hormone-sensitive cancers.
• Drug Discovery & Development: Acts as a critical intermediate or starting material in the synthesis and preclinical evaluation of new selective estrogen receptor degraders (SERDs) and related therapeutic agents.
• Metabolite Studies: Employed in the synthesis and identification of fulvestrant metabolites for pharmacokinetic and pharmacodynamic profiling.

Basic Information

Product Name	Fulvestrant (ICI 182780) R Enantiomer
CAS No.	1807900-80-6
Molecular Formula	C32H47F5O3S
Molecular Weight	606.78 g/mol
Synonyms	Fulvestrant R-Enantiomer; (7R,8R,9S,13S,14S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-diol; ICI 182780 R-Enantiomer; Faslodex Impurity (R-Form); ZD9238 R-Enantiomer
EINECS	Contact for details

Quality Control

Our Fulvestrant (ICI 182780) R Enantiomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) providing batch-specific results for all critical parameters is supplied with every order to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-Enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.