Description

1-Bromo-2-Fluoro-3-Methyl-4-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring bromo, fluoro, methyl, and nitro groups on a benzene ring, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and nitro groups contribute to enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, halogenated dyes and pigments with specific color fastness and stability properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Nucleophilic Aromatic Substitution: The combination of nitro and fluoro groups activates the ring for nucleophilic substitution, allowing for further functionalization.

Basic Information

Product Name	1-Bromo-2-Fluoro-3-Methyl-4-Nitrobenzene
CAS No.	1807209-28-4
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.03 g/mol
Synonyms	4-Bromo-3-fluoro-2-methylnitrobenzene; 2-Methyl-4-bromo-3-fluoronitrobenzene; 1-Bromo-2-fluoro-3-methyl-4-nitrobenzene; Benzene, 1-bromo-2-fluoro-3-methyl-4-nitro-; 3-Fluoro-2-methyl-4-nitrobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-3-Methyl-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.