Description

2,3-Difluoro-6-Methylbenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring strategically placed fluorine atoms and a reactive nitrile group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoromethyl moiety can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores used in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialty polymers, including high-performance resins and engineering plastics.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Used in further functionalization reactions, such as hydrolysis to carboxylic acids or reduction to benzylamines, to create a diverse array of fluorinated compounds.

Basic Information

Product Name	2,3-Difluoro-6-Methylbenzonitrile
CAS No.	1807183-03-4
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	2,3-Difluoro-6-methylbenzonitrile; 6-Methyl-2,3-difluorobenzonitrile; 2,3-Difluoro-6-methyl-benzonitrile; 2,3-Difluoro-6-toluonitrile; Benzonitrile, 2,3-difluoro-6-methyl-; 1807183-03-4
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.