Description

5-Bromo-3-Fluoro-2-Methylbenzonitrile is a high-purity, multi-functional halogenated aromatic nitrile building block. This compound is valued for its unique molecular architecture, which enables the introduction of bromine, fluorine, and nitrile functional groups into complex target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Fluorine Chemistry: The fluorine atom provides metabolic stability and influences lipophilicity, making it valuable in medicinal chemistry optimization.
• Nitrile Functionalization: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or used to construct various heterocycles like tetrazoles and triazoles.

Basic Information

Product Name	5-Bromo-3-Fluoro-2-Methylbenzonitrile
CAS No.	1807117-78-7
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Bromo-6-fluoro-3-methylbenzonitrile; 3-Fluoro-2-methyl-5-bromobenzonitrile; Benzonitrile, 5-bromo-3-fluoro-2-methyl-; 5-Bromo-3-fluoro-2-methyl-benzonitrile; 1807117-78-7
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Fluoro-2-Methylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.