Description

1-Bromo-4-Chloro-2-Fluoro-3-Nitrobenzene is a high-purity, multi-substituted aromatic building block essential for advanced organic synthesis. Its unique halogen and nitro substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro group.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex azo dyes and high-performance pigments where halogen and nitro groups influence color fastness and stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form biaryl and complex aromatic systems.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups facilitate selective substitution reactions for creating diverse chemical libraries.

Basic Information

Product Name	1-Bromo-4-Chloro-2-Fluoro-3-Nitrobenzene
CAS No.	1806970-78-4
Molecular Formula	C6H2BrClFNO2
Molecular Weight	254.44 g/mol
Synonyms	4-Bromo-1-Chloro-2-Fluoro-5-Nitrobenzene; 2-Fluoro-3-Nitro-4-Bromochlorobenzene; 1-Chloro-4-Bromo-2-Fluoro-3-Nitrobenzene; 3-Nitro-2-fluoro-4-bromo-1-chlorobenzene; Benzene, 1-bromo-4-chloro-2-fluoro-3-nitro-; BCFNB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2-Fluoro-3-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature and strong oxidizing properties, it should be segregated from incompatible materials such as reducing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.