Description

Benzonitrile, 4-Fluoro-5-Methyl-2-Nitro- CAS NO 1806475-43-3 is a high-purity, multi-substituted aromatic nitrile building block designed for advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine, nitro, and nitrile functionalities into their target structures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and nitro groups contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and polar nitrile group.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution reactions to create complex, functionalized biaryl and heteroaryl systems.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing specialized azo dyes and pigments, where the nitro group is a key chromophore component.

Basic Information

Product Name	Benzonitrile, 4-Fluoro-5-Methyl-2-Nitro-
CAS No.	1806475-43-3
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	4-Fluoro-5-methyl-2-nitrobenzonitrile; 2-Nitro-4-fluoro-5-methylbenzonitrile; 5-Methyl-4-fluoro-2-nitrobenzonitrile; 2-Cyano-5-fluoro-4-methyl-1-nitrobenzene; 1-Cyano-2-fluoro-5-methyl-4-nitrobenzene; Benzonitrile, 4-fluoro-5-methyl-2-nitro-; 1806475-43-3
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Fluoro-5-Methyl-2-Nitro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a light-proof secondary container.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.