Description

Benzonitrile, 2,5-Difluoro-4-Iodo- is a high-purity, halogenated aromatic nitrile building block with the CAS number 1806273-36-8. This compound is valued for its unique molecular architecture, which combines fluorine and iodine substituents on a benzonitrile core, making it a versatile intermediate for advanced synthesis. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, leveraging the fluorine and iodine motifs for bioactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of advanced electronic materials for displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings.
• Fluorinated Building Block: Provides a source of fluorine atoms for introducing metabolic stability and altering physicochemical properties in lead compounds.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction pathways and creating specialized chemical libraries.

Basic Information

Product Name	Benzonitrile, 2,5-Difluoro-4-Iodo-
CAS No.	1806273-36-8
Molecular Formula	C7H2F2IN
Molecular Weight	276.99 g/mol
Synonyms	2,5-Difluoro-4-iodobenzonitrile; 4-Iodo-2,5-difluorobenzonitrile; 2,5-Difluoro-4-iodo-benzonitrile; 2,5-Difluoro-4-iodobenzene-1-carbonitrile; 1-Cyano-2,5-difluoro-4-iodobenzene; Benzonitrile, 4-iodo-2,5-difluoro-; 1806273-36-8
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 2,5-Difluoro-4-Iodo- is produced and tested under a strict quality management system. We ensure the product meets the high-purity standards required for research and commercial synthesis. Comprehensive analytical techniques, including HPLC, GC, NMR, and mass spectrometry, are employed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.