Description

2,4-Difluoro-5-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a nitrile group and hydroxyl functionality on a difluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorophenol or difluoroaniline moiety.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials due to its ability to modify electronic properties and intermolecular interactions.
• Advanced Polymer Chemistry: Employed in the creation of specialty polymers and high-performance resins with tailored thermal and chemical resistance.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and the exploration of new chemical spaces.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and proprietary intermediates.

Basic Information

Product Name	2,4-Difluoro-5-Hydroxybenzonitrile
CAS No.	1806273-04-0
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	5-Hydroxy-2,4-difluorobenzonitrile; 2,4-Difluoro-5-hydroxybenzenecarbonitrile; 3-Cyano-2,6-difluorophenol; Benzonitrile, 2,4-difluoro-5-hydroxy-; 5-Cyano-2,4-difluorophenol
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Hydroxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.