Description

2-Bromo-3-Fluoro-1-Methyl-4-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the bromo and fluoro substituents can enhance biological activity.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification of chemical space.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies to introduce halogen atoms for modulating potency, metabolism, and binding affinity.
• Chemical Biology Probes: Utilized to create tagged or labeled molecules for studying biological pathways and target engagement.

Basic Information

Product Name	2-Bromo-3-Fluoro-1-Methyl-4-Nitrobenzene
CAS No.	1805938-96-8
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	1-Bromo-2-fluoro-3-methyl-6-nitrobenzene; 3-Bromo-2-fluoro-4-nitrotoluene; 2-Fluoro-3-bromo-4-nitrotoluene; 4-Nitro-2-bromo-3-fluorotoluene; Benzene, 2-bromo-3-fluoro-1-methyl-4-nitro-; Toluene, 3-bromo-2-fluoro-4-nitro-
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Fluoro-1-Methyl-4-Nitrobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support regulatory filings in target industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.