Description

3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride is a high-value, multi-functional halogenated aromatic building block. This compound matters for its unique trifluoromethyl and halogen/nitro substitution pattern, which is critical for modulating the electronic properties, lipophilicity, and metabolic stability of advanced molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups allow for selective displacement with various nucleophiles, enabling diverse chemical transformations.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Detail
Product Name	3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride
CAS No.	1805937-72-7
Molecular Formula	C7H2BrF4NO2
Molecular Weight	287.99 g/mol
Synonyms	1-Bromo-2-fluoro-3-nitro-5-(trifluoromethyl)benzene; 3-Bromo-4-fluoro-5-nitro-α,α,α-trifluorotoluene; Benzene, 1-bromo-2-fluoro-3-nitro-5-(trifluoromethyl)-; 5-Nitro-3-bromo-4-fluorobenzotrifluoride; 2-Fluoro-3-nitro-5-(trifluoromethyl)bromobenzene; α,α,α-Trifluoro-3-bromo-4-fluoro-5-nitro toluene
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its properties as a strong oxidizer, store separately from reducing agents, combustible materials, and other incompatible substances. Handle and store under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.