Description

Benzene, 2-Bromo-4-Fluoro-1-Nitro-3-(Trifluoromethyl)- is a highly functionalized aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique combination of halogen and nitro substituents, which makes it a versatile precursor for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists working on the synthesis of active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated nitrobenzene core.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups allow for selective substitution reactions, enabling precise structural modifications.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	Benzene, 2-Bromo-4-Fluoro-1-Nitro-3-(Trifluoromethyl)-
CAS No.	1805937-67-0
Molecular Formula	C7H2BrF4NO2
Molecular Weight	287.99 g/mol
Synonyms	2-Bromo-4-fluoro-1-nitro-3-(trifluoromethyl)benzene; 1-Bromo-2-fluoro-5-nitro-4-(trifluoromethyl)benzene; 3-Bromo-5-fluoro-4-nitrobenzotrifluoride; 2-Bromo-4-fluoro-1-nitro-3-(trifluoromethyl)benzene; 4-Bromo-2-fluoro-5-nitrobenzotrifluoride; 2-Bromo-4-fluoro-1-nitro-3-(trifluoromethyl)benzene (primary IUPAC); Benzene, 2-bromo-4-fluoro-1-nitro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our Benzene, 2-Bromo-4-Fluoro-1-Nitro-3-(Trifluoromethyl)- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.