Description

2-Amino-5,6-Difluorobenzonitrile is a high-value, multi-functional aromatic nitrile building block featuring both amino and fluorine substituents. This compound is essential for the synthesis of complex molecules, offering chemists a versatile handle for constructing heterocycles and introducing specific pharmacophores. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Fluorinated Dye & Pigment Development: Employed in the synthesis of novel fluorinated colorants with improved lightfastness and unique optical properties.
• Cross-Coupling Reactions: The amino and cyano groups make it a valuable substrate in palladium-catalyzed cross-coupling reactions for constructing complex biaryl systems.

Basic Information

Product Name	2-Amino-5,6-Difluorobenzonitrile
CAS No.	1805635-10-2
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	5,6-Difluoro-2-aminobenzonitrile; 2-Amino-5,6-difluorobenzene carbonitrile; 2-Cyano-4,5-difluoroaniline; Benzonitrile, 2-amino-5,6-difluoro-; 4,5-Difluoro-2-aminobenzonitrile; 2-Amino-5,6-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Amino-5,6-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.